With this win, Real Madrid on 39 points, are eight points clear of second-placed Sevilla in the La Liga 2021-22 table. Barcelone remain seventh with 23 points. It was also Barca's first loss in the La Liga since Xavi took over.
Check match and telecast details of 'El Clasico' between Barcelona and Real Madrid. Madrid lead the head-to-head record 98-96.
Vinicius scored in 51st and 56th minutes while Rodrygo (64th), Karim Benzema (90+1) and an own goal from Shakhtar captain Sergiy Kryvtsov helped Madrid.
After a near-perfect start to the season, Real Madrid are three consecutive games without a win in all competitions. Sunday's results also dropped Barcelona to ninth in La Liga.
The result means that Sheriff Tiraspol become just the second club to win on their first Champions League trip to the Bernabeu, after Arsenal in 2005-06.
Lionel Messi joined Paris Saint-Germain in a two-year deal soon after leaving Barcelona
Real Madrid may have a familiar face back in charge but Gareth Bale is still not willing to discuss his own situation at the club.
Speculation surrounds the futures of Sergio Ramos and Gareth Bale, but new boss Carlo Ancelotti hopes they remain at Real Madrid
Carlo Ancelotti has returned to Real Madrid, but he inherits a vastly different situation to that which he faced when appointed in 2013
Carlo Ancelotti was a Champions League winner in his first spell as Real Madrid boss, and the veteran Italian is returning to Los Blancos
Everton claimed their first win at Anfield since 1999 thanks to Richarlison and Gylfi Sigurdsson as Liverpool slipped to another defeat
Carlo Ancelotti dismissed rumours James Rodriguez could leave Everton, insisting the playmaker was "happy" at the club.
The Manchester clubs showed little evidence of being title challengers in the derby, while Frank Lampard lost to one of his former bosses
Chelsea's trip to Goodison Park will see Frank Lampard meet his old mentor, Carlo Ancelotti, who is now at the helm at Everton.
The Merseyside derby saw a thrilling finish at Goodison Park as Everton controversially drew 2-2 with Liverpool in the Premier League
If Liverpool avoid defeat against Everton, they will set a new club record of 23 games unbeaten against the same opponent in all competitions. Here's how to watch the Merseyside derby live
After Dominic Calvert-Lewin won the Player of the Month award, Everton boss Carlo Ancelotti took the Manager of the Month honour
Everton beat Brighton and Hove Albion on Saturday to match a run they last achieved in the 1894-95 season
Defence Minister Rajnath Singh briefs the parliament on the Indian Air Force chopper crash in Tamil Nadu yesterday, in which 13 of the 14 people on board including Chief of Defence General Staff Bipin Rawat and his wife...RSTV/PTI Photo
Opposition parties' MPs and suspended Rajya Sabha MPs observe a minute of silence for IAF Mi-17V5 helicopter crash in Tamil Nadu, in which CDS Gen Bipin Rawat, his wife Madhulika Rawat, his staff and other officials...PTI Photo/Manvender Vashist
New elected German Chancellor Olaf Scholz holds his letter of appointment presented by German President Frank-Walter Steinmeier during a reception at Bellevue Palace in Berlin, Germany. Scholz has become Germany's ninth...AP Photo/Michael Sohn
New elected German Chancellor Olaf Scholz (not in the picture) has given flowers to former Chancellor Angela Merkel during a handover ceremony in the chancellery in Berlin. Merkel was the German Chancellor for 16 years....Photo/Markus Schreiber
A surfer enters the Mediterranean Sea during stormy weather in Tel Aviv, Israel.AP Photo/Oded Balilty
Young, brash and little-known artistes are using hip-hop as an outlet to speak up and speak out.
Aamir Shaikh aka Shaikhspeare traces talks about the genre that uses music as a means to dissent.
Family from UP village forced to run around to complete post-death official paperwork and even last rites.
On BR Ambedkar's death anniversary, a look at the 'invisible' history of Dalit Bahujan women in Indian politics.
While everyone is going gaga over actress Katrina Kaif in the revamped version of 'Tip Tip Barsa Pani', the replacement of Raveena Tandon does point towards the problem of sexism and ageism in the Indian film industry
Australia winning the T20 World Cup for the first time has been timely as they host the next edition at their own backyard in 2022.
As per the Observer Research Foundation, close to 250 million children in India were adversely affected due to school closures due to the early lockdowns imposed by the government in response to Covid-19.